Theoretical Molecular Biology
Cooperation Course
Staff
Hiroyuki Ogata
- Position
- Professor
- Office
- Institute for Chemical Research, Uji Research Building 1, Room CB305
- Phone
- 0774-38-3274
- Fax
- 0774-38-3269
- ogata(at mark)kuicr.kyoto-u.ac.jp
Hisashi Endo
- Position
- Assistant Professor
- Office
- Institute for Chemical Research, Uji Research Building 1, Room CB302
- Phone
- 0774-38-3272
- Fax
- 0774-38-3269
- endo(at mark)scl.kyoto-u.ac.jp
Yusuke Okazaki
- Position
- Assistant Professor
- Office
- Institute for Chemical Research, Uji Research Building 1, Room CB302
- Phone
- 0774-38-3296
- Fax
- 0774-38-3269
- okazaki(at mark)kuicr.kyoto-u.ac.jp
Hiroyuki Hikida
- Position
- Assistant Professor
- Office
- Institute for Chemical Research, Uji Research Building 1, Room CB302
- Phone
- 0774-38-3273
- Fax
- 0774-38-3269
- hhikida(at mark)scl.kyoto-u.ac.jp
Research
In our laboratory, we analyze large-scale omics data and take theoretical and computer science approaches, including bioinformatics, to elucidate the diversity of life, the expression of biological functions, and the evolution from the viewpoint of molecules to the global environment. Specifically, we are conducting research focusing on the function and evolution of giant viruses, the function of marine microbial ecosystems, and their impact on the environment.
Giant virus function and evolution
In our laboratory, we are isolating new giant viruses using amoeba as a host. From the research so far, it has become clear that various giant viruses may exist at the same time. For example, there were more than 5,000 giant viruses in a glass of seawater collected from Osaka Bay, and there are multiple amoeba-infectious Marseille viruses in the Uji River basin. The next step is to elucidate the biological, ecological, and evolutionary significance of this local diversity. At the same time, we are studying the life cycle of giant viruses and the molecular mechanism of the infection process by making full use of omics analysis.
Functions of marine microbial ecosystems and their impact on the environment
Based on genetic data from plankton samples taken from the world’s oceans, we are investigating the basic principles of microbial ecosystem dynamics, the impact of ecosystems on the environment, and conversely the impact of changing environments on ecosystems. We are analyzing samples obtained from Uranouchi Bay (Kochi Prefecture), which is known as a red tide region, the Indian Ocean, where oxygen-deficient regions are expanding, the western North Pacific Ocean, where plankton such as diatoms are abundant, and the Arctic Ocean, where sea ice is melting due to warming. We are also conducting research on the biological carbon pumps and ecosystem inference using remote sensing technology. In addition, our laboratory is active as a core member of the international research project, Tara Oceans.