Many characteristic life phenomena emerge when cells respond to stimuli from the external environment. We are studying how cells receive and respond to stimuli from the outside world, the basic principle of information processing performed by cells. Here, external stimuli are often brought about as biomolecules with some physiological activity. And it is also biomolecules such as proteins that process the information carried by the biomolecules. In other words, the physical substance responsible for information processing in cells is a wide variety of biomolecules, and the interactions (dissociation, association and biochemical reactions) of these biomolecules according to certain rules determine the behavior of cells.

We use structural analysis methods such as nuclear magnetic resonance (NMR), X-ray crystallography, and cryo-electron microscopy, to study the intracellular information processing in the immune system, nervous system. By doing this, we aim to characterize the basic information processing mechanisms of cells.
Currently, we are conducting research on the following themes.

1. Structural elucidation of intracellular signal transduction in innate immune response
2. Elucidation of the molecular mechanism of intracellular liquid-liquid phase separation
3. Dynamic structural analysis of proteins using NMR spectroscopy
4. Analysis of GPCR structures and their interaction with G proteins